Key Publications

Proof of Concept Publications Demonstrating Utility of Zebra technology exclusively Licensed from the Scripps Research Institute

Selection of antibodies that regulate phenotype from intracellular combinatorial antibody  libraries
Zhang H, Wilson I.A, and Lerner R.A. (2012), Proc. Natl. Acad. Sci. USA109 (39):15728–15733.

Selecting agonists from single cells infected with combinatorial antibody libraries
Zhang, H., Yea, K., Xie, J., Ruiz, D., Wilson, I.A., and Lerner, R.A. (2013) Chem. Biol. 20, 734–741.

Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cells     
Xie, J., Zhang, H., Yea, K., and Lerner, R.A. (2013) Proc. Natl. Acad. Sci. USA 110, 8099–8104.

Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections  
Yea, K., Zhang, H., Xie, J., Jones, T.M., Yang, G., Song, B.D. and Lerner, R.A. (2013)  Proc. Natl. Acad. Sci. USA 

110, 14966–14971.

Prevention of Cell Death by Antibodies Selected from Intracellular Combinatorial Libraries
Xie, J., Yea, K., Zhang, H., Moldt, B., Linling He, L., Zhu, J.,and Lerner, R.A.  (2014)   Chem.Biol, 21, 274–283.

A proximity based general method for identification of ligand and receptor interactions in living  cells
Zhang, H. , Xie,j., and  Lerner, R.A.  Biochem. Biophys. Res. Com. 454 (2014) 251–255.

A general method for insertion of functional proteins within proteins via combinatorial selection of permissive junctions
Peng, Y., Zeng, W., Ye, H., Han, K.H., Dharmarajan,V., Novick, S., Wilson, I.A., Griffin, P.R., Friedman, J.M and Lerner. R.A. (2015) Chem Biol. 22:1134-43.

 Autocrine Selection of a GLP-1R G-protein Biased Agonist with Potent Anti-diabetic Effects
Zhang, H., Sturchler, E., Zhu, J., Nieto, A., Cistrone, P.A.,  Xie, J., He, L., Yea, K., Jones, T., Turn, R., DiStefano, P.S., Griffin, P.R., Dawson, P.E., McDonald, P.H. and Lerner, R.A. (2015) Nat. Commun. 6, 8918-8930.

Agonist Antibody that induces human malignant cells to kill one another
Yea, M., Zhang, H, Xie, J., Jones, T.M., Lin, C., Francesconi, W., Berton, F., Fallahi, M. ,Sauer, K., and Lerner, R.A  (2015),

Proc.Nat.Acad.Sci. 112:E6158-65.

Autocrine-Based Selection of Drugs That Target Ion Channels from Combinatorial Venom Peptide Libraries
Zhang H, Du M, Xie J, Liu X, Sun J, Wang W, Xin X, Possani LD, Yea K, Lerner RA, (2016)

Angew. Chem. Int Ed Engl. 55:9306-10.

Combinatorial antibody libraries: new advances, new immunological insights
Lerner RA. (2016), Nat Rev Immunol. 16:498-508.