Key Publications


Proof of Concept Publications Demonstrating Utility of Zebra technology exclusively Licensed from the Scripps Research Institute



2012
Selection of antibodies that regulate phenotype from intracellular combinatorial antibody  libraries
Zhang H, Wilson I.A, and Lerner R.A. (2012), Proc. Natl. Acad. Sci. USA109 (39):15728–15733.
https://www.ncbi.nlm.nih.gov/pubmed/23019357

2013                      
Selecting agonists from single cells infected with combinatorial antibody libraries
Zhang, H., Yea, K., Xie, J., Ruiz, D., Wilson, I.A., and Lerner, R.A. (2013) Chem. Biol. 20, 734–741.
https://www.ncbi.nlm.nih.gov/pubmed/23706638

Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cells     
Xie, J., Zhang, H., Yea, K., and Lerner, R.A. (2013) Proc. Natl. Acad. Sci. USA 110, 8099–8104.
https://www.ncbi.nlm.nih.gov/pubmed/23613575

Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections  
Yea, K., Zhang, H., Xie, J., Jones, T.M., Yang, G., Song, B.D. and Lerner, R.A. (2013)  Proc. Natl. Acad. Sci. USA 

110, 14966–14971.

https://www.ncbi.nlm.nih.gov/pubmed/23980154

 2014                      
Prevention of Cell Death by Antibodies Selected from Intracellular Combinatorial Libraries
Xie, J., Yea, K., Zhang, H., Moldt, B., Linling He, L., Zhu, J.,and Lerner, R.A.  (2014)   Chem.Biol, 21, 274–283.
https://www.ncbi.nlm.nih.gov/pubmed/24440080


A proximity based general method for identification of ligand and receptor interactions in living  cells
Zhang, H. , Xie,j., and  Lerner, R.A.  Biochem. Biophys. Res. Com. 454 (2014) 251–255. https://www.ncbi.nlm.nih.gov/pubmed/25451250

 2015                       
A general method for insertion of functional proteins within proteins via combinatorial selection of permissive junctions
Peng, Y., Zeng, W., Ye, H., Han, K.H., Dharmarajan,V., Novick, S., Wilson, I.A., Griffin, P.R., Friedman, J.M and Lerner. R.A. (2015) Chem Biol. 22:1134-43.

https://www.ncbi.nlm.nih.gov/pubmed/26278185

 Autocrine Selection of a GLP-1R G-protein Biased Agonist with Potent Anti-diabetic Effects
Zhang, H., Sturchler, E., Zhu, J., Nieto, A., Cistrone, P.A.,  Xie, J., He, L., Yea, K., Jones, T., Turn, R., DiStefano, P.S., Griffin, P.R., Dawson, P.E., McDonald, P.H. and Lerner, R.A. (2015) Nat. Commun. 6, 8918-8930.
https://www.ncbi.nlm.nih.gov/pubmed/26621478

Agonist Antibody that induces human malignant cells to kill one another
Yea, M., Zhang, H, Xie, J., Jones, T.M., Lin, C., Francesconi, W., Berton, F., Fallahi, M. ,Sauer, K., and Lerner, R.A  (2015),

Proc.Nat.Acad.Sci. 112:E6158-65.

https://www.ncbi.nlm.nih.gov/pubmed/26487683

2016                     
Autocrine-Based Selection of Drugs That Target Ion Channels from Combinatorial Venom Peptide Libraries
Zhang H, Du M, Xie J, Liu X, Sun J, Wang W, Xin X, Possani LD, Yea K, Lerner RA, (2016)

Angew. Chem. Int Ed Engl. 55:9306-10.

https://www.ncbi.nlm.nih.gov/pubmed/27197631

Combinatorial antibody libraries: new advances, new immunological insights
Lerner RA. (2016), Nat Rev Immunol. 16:498-508.
https://www.ncbi.nlm.nih.gov/pubmed/27374636